1040 - the Effect of Osteogenic Protein-1 on Intervertebral Disc Cells Pre-exposed to Interleukin-1
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چکیده
*Takegami, K; *Masuda, K (A-NIH, Stryker Biotech); **An, H (A-Stryker Biotech); *Kamada, H; ***Pietryla, D; +****Thonar, E (A-NIH, Stryker Biotech) *Depts. of Biochem. and Orthop. Surg., Rush Medical College, Chicago, IL. +****Depts. of Biochem., Orthop. Surg. and Internal Medicine, Rush Medical College at Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL. 1653 W. Congress Parkway, Chicago, IL, 312-942-2163, Fax: 312-942-3053, [email protected]
منابع مشابه
Degenerative Disc Disease: A Review of Cell Technologies and Stem Cell Therapy
Background & Aim: Low back pain is broadly documented as one of the most widespread pathologies in the advanced domain. Although the reasons of low back pain are uncountable, it has been meaningfully related to intervertebral disc degeneration. Present therapies for Intervertebral Disc (IVD) degeneration such as physical therapy and spinal fusion reduce symptoms' severity, but do not treat the ...
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Intervertebral disc (IVD) degeneration is the most common cause of back pain. Presently there is no medical treatment, leaving surgery as the only offered option. Here we evaluate the potential of Link-N to promote extracellular matrix regeneration in human IVDs. Human disc cells cultured in alginate and intact human discs were exposed to a combination of Link-N and ³⁵SO₄ in the presence or abs...
متن کاملIntradiscal Injection of Osteogenic Protein-1 Can Restore Viscoelastic Properties of Degenerated Intervertebral Discs
Fig. 3 Effect of OP-1 on biochemical properties of rabbit IVDs. Fig. 4 Relationship between biochemical and biomechanical properties INTRADISCAL INJECTION OF OSTEOGENIC PROTEIN-1 CAN RESTORE VISCOELASTIC PROPERTIES OF DEGENERATED INTERVERTEBRAL DISCS *Miyamoto, K; +***Masuda, K; Kim, JG; *Inoue, N; *Akeda, K; *Andersson, GBJ; *An, HS Depts. of +*Orthopedic Surgery and **Biochemistry, Rush Unive...
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Background: The purpose of this study was to identify the effects of eight weeks of conventional and suspension corestability exercises by use of the designed device on characteristic of intervertebral discs in low back pain.Methods: A total of 27 men with chronic low back (CLB) pain due to lumbar disc herniation in L4-L5 and L5-S1 regionswere enrolled in this quasi-experiment...
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INTRODUCTION Excessive mechanical loading of intervertebral discs (IVDs) is thought to alter matrix properties and influence disc cell metabolism, contributing to degenerative disc disease and development of discogenic pain. However, little is known about how mechanical strain induces these changes. This study investigated the cellular and molecular changes as well as which inflammatory recepto...
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